Showing results for Alzheimer's disease

Researchers discover new insights into how gene associated with Alzheimer's disease affects healthy brains

A new study from researchers at the IU School of Medicine provides a key resource for investigators to better understand disease-specific and sex-specific effects of a gene associated with Alzheimer's disease before the onset of the disease.

IU School of Medicine | Jun 26, 2024

Increased expression of gene improves Alzheimer's disease symptoms

A new study by IU School of Medicine researchers has found that increased expression of a gene linked to Alzheimer's disease helped improve characteristics of the disease in mouse models. Gene expression is a series of molecular events that turns on particular parts of the DNA to inform how cells function.

IU School of Medicine | Jun 18, 2024

a close up photo of gloved hands preparing a sample in the lab

IU researchers receive $4.8 million grant to study the role of misfolded protein TDP-43 in neurodegenerative diseases

A new $4.8 million grant will support researchers from Indiana University School of Medicine and the Medical Research Council Laboratory of Molecular Biology to study how human neurodegenerative diseases are affected by the misfolding of the protein TDP-43.

IU School of Medicine | Apr 23, 2024

figure shows Aβ and tau filaments in DS brain with Cryo-EM maps, depicted as central slices, of type I and II Aβ42 filaments (A), type IIIa and IIIb Aβ40 filaments (B), and tau filaments (C). Type IIIb Aβ40 filaments are organized as a dimer of dimers composed by two pairs of non-identical protofilaments.

High-resolution images reveal similarities in protein structures between Alzheimer’s disease and Down syndrome

A new study recently published in Nature Structural and Molecular Biology uses leading-edge cryo-electron microscopy imaging technology to determine whether differences exist between the protein structures in those with Alzheimer’s disease and those with both Alzheimer’s disease and Down syndrome.

IU School of Medicine | Mar 29, 2024

Five IU School of Medicine faculty honored among nation's top physician-scientists

Five Indiana University School of Medicine faculty have been recognized among the nation's top physician-scientists as 2024 members of the Association of American Physicians (AAP) and the American Society for Clinical Investigation (ASCI).

IU School of Medicine | Mar 26, 2024

A researcher in the Department of Medical and Molecular Genetics

IU School of Medicine's 2023 NIH funding ranked No. 13 among public universities

Indiana University School of Medicine researchers received over $243 million in total funding from the National Institutes of Health during federal fiscal year 2023 — a more than $54 million increase over the past five years, or 28%.

IU School of Medicine | Feb 20, 2024

$3.4 million grant to fund research on brain bleeding, swelling that occurs in quarter of patients who receive Alzheimer’s disease treatments

With the emergence of promising treatments that slow the cognitive decline of Alzheimer’s disease in patients, there are still questions surrounding side effects of the drugs. An Indiana University School of Medicine researcher is among the few neuroscientists investigating these adverse events, which can cause brain swelling and brain bleeding.

IU School of Medicine | Feb 14, 2024

Protein found in brain linked to frontotemporal dementia

An international team of researchers including experts at the Indiana University School of Medicine has identified a protein found in the brains of people with frontotemporal dementia (FTD), discovering a new target for potential treatments for the disease.

IU School of Medicine | Dec 07, 2023

IU researchers develop new brain network modeling tools to advance Alzheimer's disease research

Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools—previously developed to analyze brains of patients in the clinic—to investigate Alzheimer’s disease progression in preclinical animal models.

IU School of Medicine | Nov 30, 2023

A researcher works in a IU School of Medicine biomarker lab.

IU scientists part of NIH-funded national consortium focused on improving Alzheimer’s disease diagnoses

Researchers at Indiana University School of Medicine will play key roles in a national consortium led by Wake Forest University School of Medicine to study the use, interpretation and implementation of biomarkers to diagnose Alzheimer’s disease.

IU School of Medicine | Oct 27, 2023