Andrew Saykin's, PsyD research program focuses on precision medicine for the early detection of Alzheimer’s disease and related dementias. His laboratory utilizes the integration of advanced multimodal high throughput neuroimaging, cognitive neuroscience, and multiple “omics” data, such as gene and protein/metabolite networks, to identify novel biomarkers of disease mechanisms and potential therapeutic targets of disease. Saykin’s research also encompasses the study of cognitive/memory deficits as they relate to cancer, traumatic brain injury, temporal lobe epilepsy, schizophrenia and other brain diseases.
Get involved
Saykin discusses path toward precision medicine
![Chart showing Network Analysis of Longitudinal Endophenotypes and Systems Biology and Functional Genomics](https://mc-42b990dd-5dae-4647-b81e-424724-cdn-endpoint.azureedge.net/-/media/s/saykin_lab.png?h=389&w=350&rev=46c9f091597b4942b20176d2932a6063&hash=B7EA3461476D9300D85946D1F55E34E0)
This information is integrated with advanced analytics that utilize multi-omics datasets, such as transcriptomics, metabolomics, proteomics, and genomics, in a systems biology approach that simulates complex biological systems and interactions. In unison, these complex tools aid in the identification of biomarkers for early risk, which are important for characterizing pathophysiology, identifying novel targets for therapeutic development and assessing the response to treatment.
-
P30AG072976 (PI: Saykin)
Indiana Alzheimer’s Disease Research Center (IADRC)
-
5R01AG019771-15 (PI: Saykin)
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular Drivers
-
R01 AG068193 (PI: Mandelblatt; MPI: Saykin)
Cognitive Aging, Alzheimer’s disease, and Cancer-related Cognitive Decline
-
U01 AG068057 (PI: Thompson; MPIs: Davatzikos, Huang, Saykin, Shen)Ultrascale Machine Learning to Empower Discovery in Alzheimer’s Disease Biobanks
-
U01AG072177 (PI: Saykin; MPIs: Nho, Lee)
Korean Brain Aging Study, Longitudinal Endophenotypes and Systems Biology
-
2U19AG024904-16 (PI: Saykin)Genetics Core
Northern California Institute/Res/Edu -
T32 AG071444 (PI: Landreth; MPIs: Lamb & Saykin)
Training Grant on Alzheimer's Disease and ADRD at Indiana University
-
R01 LM013463 (PI: Shen; MPIs: Moore, Saykin)Informatics Algorithms for Genomic Analysis of Brain Imaging Data
-
RF1 AG058942 (Kaddurah-Daouk) (Site PI: Saykin)Duke University (Prime: NIH)
Gut Liver Brain Biochemical Axis in Alzheimer’s Disease -
5R01AG057739-05 (MPIs: Perry, Apostolova, Saykin)Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's Disease
![6962-Saykin, Andrew 6962-Saykin, Andrew](https://mc-42b990dd-5dae-4647-b81e-424724-cdn-endpoint.azureedge.net/-/media/project/facultyprofileimages/2021/02/06/14/43/6962-andrew-saykin.png?rev=85d9b06b10144694967816b5c4cd3ccc&h=120&w=80&la=en&hash=AF0889CDC2C2F7F5C833966D70A03B8A)
Andrew J. Saykin, PsyD
Director, Center for Neuroimaging and Indiana Alzheimer's Disease Research Center
![7297-McDonald, Brenna 7297-McDonald, Brenna](https://mc-42b990dd-5dae-4647-b81e-424724-cdn-endpoint.azureedge.net/-/media/project/facultyprofileimages/2021/02/06/15/06/7297-brenna-mcdonald.png?rev=10cc970b955d4c768bca76e1909fb2ac&h=120&w=80&la=en&hash=15B166C53B390A2ADACE4212EAE8F653)
Brenna C. McDonald, PsyD
Professor of Radiology & Imaging Sciences
![7050-Risacher, Shannon 7050-Risacher, Shannon](https://mc-42b990dd-5dae-4647-b81e-424724-cdn-endpoint.azureedge.net/-/media/project/facultyprofileimages/2021/02/07/16/45/7050-shannon-risacher.png?rev=0372c76128e54e9c9e5871b08bd01152&h=120&w=80&la=en&hash=03A80DF371BED4D3DA9D0EB2C01B5C01)
Shannon L. Risacher, PhD
Associate Professor of Radiology & Imaging Sciences
![Faculty Profile Picture Placeholder IUSM Logo](/FrontEnd/Images/faculty-placeholder.png)
Paula J. Bice, PhD
Assistant Research Professor of Radiology & Imaging Sciences
![27197-Mathew, Sunu 27197-Mathew, Sunu](https://mc-42b990dd-5dae-4647-b81e-424724-cdn-endpoint.azureedge.net/-/media/project/facultyprofileimages/2023/01/06/21/19/27197-sunu-mathew.png?rev=edfb154c8fd4433ca52e1d473dbe171f&h=120&w=80&la=en&hash=DED4A2E11ADE5CDCCDB9264D1A8FC8DE)
Sunu Mathew, M.D.
Assistant Research Professor of Radiology & Imaging Sciences
![Faculty Profile Picture Placeholder IUSM Logo](/FrontEnd/Images/faculty-placeholder.png)
Evgeny Jenya Chumin, PhD
Medical Neuroscience
![Faculty Profile Picture Placeholder IUSM Logo](/FrontEnd/Images/faculty-placeholder.png)
Cecily Swinford, PhD
Medical Neuroscience
![Faculty Profile Picture Placeholder IUSM Logo](/FrontEnd/Images/faculty-placeholder.png)
Thea Rosewood, PhD
Medical and Molecular Genetics
![Faculty Profile Picture Placeholder IUSM Logo](/FrontEnd/Images/faculty-placeholder.png)
Soumilee Chaudhuri
![Faculty Profile Picture Placeholder IUSM Logo](/FrontEnd/Images/faculty-placeholder.png)
Kaitlyn Dybing
![Faculty Profile Picture Placeholder IUSM Logo](/FrontEnd/Images/faculty-placeholder.png)
Desarae Dempsey
![Faculty Profile Picture Placeholder IUSM Logo](/FrontEnd/Images/faculty-placeholder.png)
Lauren Hirschfeld